The molecular mechanism of temperature‐dependent sex determination (TSD) is a long‐standing mystery. How is the thermal signal sensed, captured and transduced to regulate key sex genes? Although there is compelling evidence for pathways via which cells capture the temperature signal, there is no known mechanism by which cells transduce those thermal signals to affect gene expression. Here we propose a novel hypothesis we call 3D‐TSD (the three dimensions of thermolabile sex determination). We postulate that the genome has capacity to remodel (...) in response to temperature by changing 3D chromatin conformation, perhaps via temperature‐sensitive transcriptional condensates. This could rewire enhancer–promoter interactions to alter the expression of key sex‐determining genes. This hypothesis can accommodate monogenic or multigenic thermolabile sex‐determining systems, and could be combined with upstream thermal sensing and transduction to the epigenome to commit gonadal fate. (shrink)

© 2017. The American Astronomical Society. All rights reserved.We present new observations of the low-mass companion to HD 984 taken with the Gemini Planet Imager as a part of the GPI Exoplanet Survey campaign. Images of HD 984 B were obtained in the J and H bands. Combined with archival epochs from 2012 and 2014, we fit the first orbit to the companion to find an 18 au orbit with a 68% confidence interval between 14 and 28 au, an eccentricity (...) of 0.18 with a 68% confidence interval between 0.05 and 0.47, and an inclination of 119°with a 68% confidence interval between 114°and 125°. To address the considerable spectral covariance in both spectra, we present a method of splitting the spectra into low and high frequencies to analyze the spectral structure at different spatial frequencies with the proper spectral noise correlation. Using the split spectra, we compare them to known spectral types using field brown dwarf and low-mass star spectra and find a best-fit match of a field gravity M6.5 ±1.5 spectral type with a corresponding temperature of K. Photometry of the companion yields a luminosity of log=2.88 ± 0.07 dex with DUSTY models. Mass estimates, again from DUSTY models, find an age-dependent mass of 34 ±1 to 95 ±4 M Jup. These results are consistent with previous measurements of the object. (shrink)

This book departs from much of the scholarship on Kant by demonstrating the centrality of imagination to Kant's philosophy as a whole. In Kant's works, human experience is simultaneously passive and active, thought and sensed, free and unfree: these dualisms are often thought of as unfortunate byproducts of his system. Gibbons, however, shows that imagination performs a vital function in "bridging gaps" between the different elements of cognition and experience. Thus, the role imagination plays in Kant's works expresses his fundamental (...) insight into the complexity of cognition for finite rational beings such as ourselves. (shrink)

The authors conducted a baseline survey of baccalaureate and graduate degree health humanities programs in the United States and Canada. The object of the survey was to formally assess the current state of the field, to gauge what kind of resources individual programs are receiving, and to assess their self-identified needs to become or remain programmatically sustainable, including their views on the potential benefits of program accreditation. A 56-question baseline survey was sent to 111 institutions with baccalaureate programs and 20 (...) institutions with graduate programs. Respondents were asked about three areas: (1) program administration (managing unit, paid director, faculty lines, paid staff, funding sources); (2) educational program (curricular structure, CIP code usage, completion rates); and (3) views on accreditation for the field. A clear majority of respondents agreed that some form of accreditation or consultation service could address resource and sustainability issues. Overall, the survey responses to staffing, curricular structure, and support suggest the need for developing a sustainable infrastructure for health humanities. (shrink)

The performance of 93 children aged 3 and 4 years on a battery of different counterfactual tasks was assessed. Three measures: short causal chains, location change counterfactual conditionals, and false syllogisms—but not a fourth, long causal chains—were correlated, even after controlling for age and receptive vocabulary. Children's performance on our counterfactual thinking measure was predicted by receptive vocabulary ability and inhibitory control. The role that domain general executive functions may play in 3- to 4-year olds' counterfactual thinking development is discussed.

Merker, Williford, and Rudrauf make several arguments against the integrated information theory of consciousness; whereas some have merit, their conclusion that the theory should be discarded is premature. Coming years promise advances in the empirical study of consciousness, and only after theories are independently tested with shared data can they be ruled in or out. We propose future research directions.

This book departs from much of the scholarship on Kant by demonstrating the centrality of imagination to Kant's philosophy as a whole. In Kant's works, human experience is simultaneously passive and active, thought and sensed, free and unfree: these dualisms are often thought of as unfortunate byproducts of his system. Gibbons, however, shows that imagination performs a vital function in "bridging gaps" between the different elements of cognition and experience. Thus, the role imagination plays in Kant's works expresses his fundamental (...) insight into the complexity of cognition for finite rational beings such as ourselves. (shrink)

This book traces the historic transformation of institutional review boards (IRBs) from academic committees to compliance bureaucracies. Sarah Babb opens the black box of contemporary IRB decision-making, which is increasingly outsourced to specialized private firms.

A Pulitzer Prize–winning dance critic teaches us to appreciate—and enact—grace in every dimension, from the physical to the emotional. Grace has long been taught as essential to civilized living. The Three Graces—goddesses of charm, beauty, and creativity—exemplify ease and harmony with one another and the world around them. But what has happened to this simple, marvelous concept of being at ease in the world? With warmth, humor, and an ever-perceptive eye, Sarah L. Kaufman sifts the graceful from the graceless, (...) celebrating heart-catching moments of physical elegance in sports, movies, dance, fashion, and music; rare sightings of celebrity grace; the secrets of gracious hosts; and grace found unexpectedly, in the kitchen of a high-end restaurant and among strippers in a basement bar. Kaufman’s thought-provoking reflections on these physical and social acts of grace offer hope for even the clumsiest, most awkward among us. Guided by the muse of Cary Grant (with further inspiration from Smokey Robinson, Roger Federer, Nelson Mandela, Margot Fonteyn, Amy Purdy, Beyoncé, and others), Kaufman illuminates the importance of grace in the small moments of everyday life. In The Art of Grace, she inspires us to walk taller, spend time on unnecessary kindnesses, and celebrate the grace notes in our lives and those of others. (shrink)

Historically, male sexual fitness was framed by a patriarchal politics of life centred on regeneration, population and nation. In the later 20th century, as successful ageing became promoted by the lifestyle practices of an idealized healthy and active senior citizenry, traditional gerontocratic power over the sexual risks of youth gave way to a medical sexology concerned with sexual functionality across the lifecourse; in particular, erectility. Recently, erectile dysfunction has expanded to become a population-wide health problem with increasingly refined diagnoses based (...) on `phases', `early warning signs' and preventative regimes, especially as Viagra has become so widely available. This article explores a new bodily configuration in the making; arising, on the one hand, from the pharmacological and scientific technologization of male sexuality, and, on the other, from a contemporary politics of life that both contests the late-life ageism of the past and fosters a mid-life ageism in the present. (shrink)

This book departs from much of the scholarship on Kant by demonstrating the centrality of imagination to Kant's philosophy as a whole. In Kant's works, human experience is simultaneously passive and active, thought and sensed, free and unfree: these dualisms are ofen thought of as unfortunate byproducts of his system. Gibbons, however, shows that imagination performs a vital function in 'bridging gaps' between the different elements of cognition and experience. Thus, the role imagination plays in Kant's works expresses his fundamental (...) insight into the complexity of cognition for finite rational beings such as ourselves. Gibbons begins with an interpretation of synthesis which shows it to be a broader activity than most accounts suggest. Examining the first Critique, she presents a reading of the Transcendental Deduction and the chapter on Schematism that spells out the extraconceptual activities of imagination essential to cognition. This account of imagination is built upon in the Critique of Judgment, where Kant elaborates its role in characterizing the subjective conditions of judgement. Throughout, the cooperation of imagination and reason is highlighted; Gibbons shows that on Kant's account, human beings pursue reason's ideal ends through the provisional and continuing attempt to articulate them. This attempt involves an appeal to a shared social and historical imagination - thus, a full characterization of the subjective conditions of judgement must include the role of imagination. (shrink)

The need for informed analyses of health policy is now greater than ever. The twelve essays in this volume show that public debates routinely bypass complex ethical, sociocultural, historical, and political questions about how we should address ideals of justice and equality in health care. Integrating perspectives from the humanities, social sciences, medicine, and public health, this volume illuminates the relationships between justice and health inequalities to enrich debates. Understanding Health Inequalities and Justice explores three questions: How do scholars approach (...) relations between health inequalities and ideals of justice? When do justice considerations inform solutions to health inequalities, and how do specific health inequalities affect perceptions of injustice? And how can diverse scholarly approaches contribute to better health policy? From addressing patient agency in an inequitable health care environment to examining how scholars of social justice and health care amass evidence, this volume promotes a richer understanding of health and justice and how to achieve both. -/- The contributors are Judith C. Barker, Paula Braveman, Paul Brodwin, Jami Suki Chang, Debra DeBruin, Leslie A. Dubbin, Sarah Horton, Carla C. Keirns, J. Paul Kelleher, Nicholas B. King, Eva Feder Kittay, Joan Liaschenko, Anne Drapkin Lyerly, Mary Faith Marshall, Carolyn Moxley Rouse, Jennifer Prah Ruger, and Janet K. Shim. (shrink)

Metabolic Syndrome is a cluster of risk factors (including obesity, hypertension and insulin resistance), which is associated with late‐onset diabetes and coronary heart disease. Elevated levels of the protease inhibitor PAI‐1 are well‐known molecular markers of the Metabolic Syndrome. Here, however, we present a hypothesis that PAI‐1 acts as a causative factor in the development of Metabolic Syndrome and its clinical sequelae. We propose that PAI‐1 inhibits the activity of members of the proprotein convertase (PC) class of serine proteases and (...) that this underlies, at a molecular level, many of the other features of the Metabolic Syndrome cluster. BioEssays 28: 629–641, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

With the rising interest in the field of trauma research, many Institutional Review Boards, policymakers, parents, and others grapple with the impact of trauma-research participation on research participants' well-being. Do individuals who participate in trauma-focused research risk experiencing lasting negative effects from participation? What are the potential benefits that may be gleaned from participation in this work? How can trauma research studies be designed ethically, minimizing the risk to participants? The following review seeks to answer these questions. This review indicates (...) that most studies in this area have found that only a minority of participants experience distress when participating in trauma-focused research. Furthermore, these negative feelings tend to dissipate quickly over time, with the majority of participants self-appraising their participation as positive, rewarding, and beneficial to society. Design characteristics that may serve to minimize participants' risk of experiencing distress are discussed, as well as implications for public policy and future research. (shrink)

Results of genetic analyses show that social groups of female and immature sperm whales are comprised of multiple matrilines as evidenced by the presence of multiple mitochondrial (maternally inherited) control region haplotypes. These data suggest: (1) a social environment in which the transmission of cultural information, such as vocal dialects, is more likely to be horizontal or oblique rather than strictly vertical (mother-offspring) and (2) lead us to question the data presented to support gene-culture coevolution.

With increasing technological improvements, production processes are becoming more and more automated. Nevertheless, full automation is improbable in the medium term since human abilities cannot yet be completely replaced. Therefore, it is likely that so-called hybrid human–robot teams will assume the future production. This raises questions regarding the shaping of future production and the effects it will have on the employees, workstations, and the companies as a whole. The project “Work in the Industry of the Future” addresses the entirely new (...) cooperative relationship between man and technology in the Industry 4.0 and its impact on opportunities for the work force. To derive the requirements and effects of hybrid workplaces, an initial work analysis of existing workplaces with varying levels of technological enhancement will be conducted. Multiple standardized work analysis instruments that vary in method, duration, level of analysis, and recorded characteristics already exist. This paper gives an overview of an assortment of these methods that can be used in production. (shrink)

In Book 10 of the Aeneid, Virgil presents an epic catalogue of Etruscan allies who return under Aeneas' command to the beleaguered Trojan camp, including the forces from Liguria. The account of the Ligurians initially conforms to the general pattern of the catalogue, as Virgil briefly introduces and describes the two leaders. But the description of Cupauo's swan-feather crest leads to a digression about the paternal origins of the avian symbol. Cupauo's father Cycnus, stricken with grief for his beloved Phaethon, (...) was transformed from a mournful singer into the swan that bears his name : non ego te, Ligurum ductor fortissime bello,transierim, Cinyre, et paucis comitate Cupauo,cuius olorinae surgunt de uertice pennae formaeque insigne paternae.namque ferunt luctu Cycnum Phaethontis amati,populeas inter frondes umbramque sororum 190dum canit et maestum Musa solatur amorem,canentem molli pluma duxisse senectamlinquentem terras et sidera uoce sequentem. Virgil not only places the Ligurians in a central position within the catalogue, but also devotes more verses to them than to any other contingent, including his own Mantuans. At the very heart of this prominent passage lies the embedded tale of Cycnus, the erotic and sorrowful centrepiece of Virgil's Etruscan catalogue. (shrink)

Much research in the field of emotions has shown that people differ in the cues that they use to perceive their own emotions. People who are more responsive to personal cues (personal cuers) make use of cues arising from their own bodies and behavior; people who are less responsive to personal cues (situational cuers) make use of cues arising from the world around them. An evolutionary explanation of this well-documented phenomenon is that it occurs because of the operation of a (...) cognitive module designed to enable the organism to predict its own impending behavior. This theory suggests that situational cuers would be people for whom external factors are the best source of information about their own future behavior, whereas personal cuers are people for whom cues about themselves are the best source of information about their own future behavior. Such a view is founded in the New Realist philosophy of the early twentieth century, a philosophy that affected psychology through the work of E. C. Tolman and J. J. Gibson. (shrink)

This article discusses the definitions of faith of three twentieth-century Jewish-Christian mystic philosophers: Simone Weil, Hannah Arendt, and Gillian Rose. Weil’s “attente de Dieu” (waiting for God), Arendt’s “natality,” and Rose’s immanence each reflect an attention to the world in understanding the workings of faith. In this context, faith and hope are not cheap optimisms or escapisms into the transcendent, but a patient reckoning with the pains of the world and human relationships.

Overwhelming evidence points to the existence of separate sensory channels in the nervous system. The power of this type of parallel organization is that information is first processed in neurons specialized to code it most efficiently. However, sensory pathways are convergent and divergent at each level as well, as is necessary to interpret multimodal and conflicting information.

Managers seeking to respect local norms when operating in cross-cultural settings may encounter ethical dilemmas when faced with values that potentially conflict with their own. The question of whose ethics or values should be applied or whether a set of universal ethical norms should be developed often confronts managers in their international business dealings. This article explores the findings from a qualitative research study that examines critical ethical dilemmas confronting Australian managers in their international business operations and their responses to (...) those dilemmas. For Australians managers in this study, bribery emerged as the major ethical dilemma confronting them in their international operations. (shrink)

This essay examines Harriet Jacobs’s Incidents in the Life of a Slave Girl (1861) in light of new archival findings on the medical practices of Dr. James Norcom (Dr. Flint in the narrative). While critics have sharply defined the feminist politics of Jacobs’s sexual victimization and resistance, they have overlooked her medical experience in slavery and her participation in reform after escape. I argue that Jacobs uses the rhetoric of a woman-led health reform movement underway during the 1850s to persuade (...) her readers to end slavery. This essay reconstructs both contexts, revealing that Jacobs links enslaved women’s physical and sexual vulnerability with her female readers’ fears of male doctors’ threats to modesty and of their standard bleed-and-purge treatments. Jacobs illustrates that slavery damages women’s health as much as heroic medicine, and thus merits the political activism of her readers. Specifically, Jacobs dramatizes her conflicts with the rapacious physician-master at moments that are crucial to women’s health: marriage, pregnancy, childbirth, and motherhood. Ultimately, this essay advances a new understanding of the role of health reform in social change: it galvanized other movements such as women’s rights and abolition, particularly around issues of bodily autonomy for women and African Americans. (shrink)

Following from sweeping law reforms across the global health landscape, there is a need to prepare the next generation to advance global health law to ensure justice for a healthier world. Educational programs across disciplines have increasingly incorporated the field of global health law, with new courses examining the law and policy frameworks that apply to the new set of public health threats, non-state actors, and regulatory instruments that structure global health. Such interdisciplinary training must be expanded throughout the world (...) to prepare future practitioners to strengthen global health law — ensuring a foundation for global health in legal studies and law and global health studies. Meeting this imperative for global health law teaching — establishing academic courses and textbooks on global legal responses to shared health threats — will be necessary to support students to address the global health challenges of the future. (shrink)

This article explores the intellectual life of Max Harold Fisch, the twentieth-century American scholar of Giambattista Vico and Charles S. Peirce. Fisch was a thinker with fundamental commitments to both history and philosophy. The claim here is that his life exemplifies a constitutive tension in the work of intellectual historians, who operate in the interstice between these two disciplines. What we learn is that intellectual historians may have a double investment both in the filigree of particular historical contexts and in (...) the principles that emerge in and then detach from those contexts. The article explores this double investment by following it through five decades of Fisch’s intellectual labor between 1930 and 1980. (shrink)

We propose an experimental method to study the possible emergence of sensemaking in artificial agents. This method involves analyzing the agent's behavior in a test bed environment that presents regularities in the possibilities of interaction afforded to the agent, while the agent has no presuppositions about the underlying functioning of the environment that explains such regularities. We propose a particular environment that permits such an experiment, called the Small Loop Problem. We argue that the agent's behavior demonstrates sensemaking if the (...) agent learns to exploit regularities of interaction to fulfill its self-motivation as if it understood (at least partially) the underlying functioning of the environment. As a corollary, we argue that sensemaking and self-motivation come together. We propose a new method to generate self-motivation in an artificial agent called interactional motivation. An interactionally motivated agent seeks to perform interactions with predefined positive values and avoid.. (shrink)

Review of: God's word 2019: Daily reflections, liturgical diary, by Strathfield, NSW: St Pauls, 2018), pp. 464, $16.95; 365 days with the lord 2019: Liturgical biblical diary, by Makati City, Philippines: St Pauls, 2018), pp. 400, $22.95.

Pro-anorexia is an Internet-based movement that provides advice and support for the development/maintenance of an eating disorder. The movement is sometimes framed as a religion, with rituals, psalms, creeds and the invocation of a deity who personifies the ED. The latter aspect is likely to influence identities and behaviours as well as providing emotional support and motivation for community members. However, there is little sustained empirical analysis of how members themselves orient to and self-position within the religious discourse. Here, we (...) apply the concept of interdiscursivity to examine the construction of Ana as god. Drawing on a body of online interactions from one pro-ana website over a 47-day period, we discursively analyse members’ constructions of Ana and their relationship with her. With reference to biblical texts, we consider how these constructions directly reference concepts of Christian religion and faith. Implications for understanding pro-ana and interdiscursivity are discussed. (shrink)

The study is carried out in five chapters, with the first two offering a reconsideration of the function of the imagination in the Transcendental Deduction and Schematism of the first Critique. The last three follow the order of topics discussed by Kant in the third Critique in regard to judgments of taste, the sublime, and teleology; they conclude with an interpretation of "productive imagination" as a "model for the ideal of intellectual intuition". The comparison between "human and divine spontaneity" is (...) introduced in the first chapter, where Gibbons notes that while we have "Kant's explicit and repeated emphasis on the difference" between these, "in considering the similarity of these types of spontaneity," she wishes "to correct a possible imbalance in Kant's exposition": there are, she suggests, "formal similarities between these types of spontaneity". The main thrust of the first chapter is to respond to a particular reading of Kant—namely, to those unsympathetic interpreters who see in the Deductions an "imaginary subject of transcendental psychology" and also to those who give a "sympathetic reading" but do so in terms of an identification of "all aspects of synthesis with concept application," thereby reducing the "role of the transcendental synthesis of the imagination to that of unifying a manifold of intuition under a concept". Gibbons holds instead that the "theory of synthesis... focuses on the nature of human cognition and what is required for us to know anything about objects" and, further, that it presupposes "the broader function of the imagination as grounding the possibility of concept-application in the first place". (shrink)

Gilles Deleuze and belief in the world -- A struggle against oneself: cinema as technology of the self -- The evidence of film and the presence of the world: Jean-Luc Nancy's cineastic ontology -- Cinema as human art: rescuing aura in gesture -- Exhibiting or presenting?: politics, aesthetics and mysticism in Benjamin's and Deleuze's concepts of cinema -- Made and yet true: on the aesthetics of presence of the heroic -- An art of gesture: returning narrative and movement to images (...) -- It is if we could trust: fiction and aesthetics of the political -- All you need is love: Cavell and the comedy of remarriage of film and philosophy. (shrink)

The paper by Bergnar and Bunford in this edition of Philosophy, Psychiatry, & Psychology is a sophisticated examination of a central question that has lacked consensus in the philosophy of psychiatry, namely, what is “the key aspect of the meaning of this fundamental term, mental disorder”? To settle this question, the authors use an empirical approach by surveying graduate students in clinical psychology. In this way, they attempt to invoke the Wittgensteinian method of determining the meaning of a term by (...) seeing how it is used. The empirical results, the authors argue, serve as strong evidence in support of the position that the term ‘mental disorder’ designates disability... (shrink)

Fertility preservationFertility preservation is increasingly available to pediatric and adolescentAdolescents populations whose future fertility is threatened. These reproductive technologies raise questions about the interestsInterest of younger children in future fertility, parental interestsInterest and influences on adolescentsAdolescents, and the interestsInterest of persons no longer living. Ethical and legal analyses of specific case examples highlight key issues of parental permissionParental permission and minorMinorassentAssent, emerging adolescentAdolescentsautonomyAutonomy, and postmortemRetrieval, gametegamete retrievalGamete retrieval.

What happens when we blur time and allow ourselves to haunt or to become haunted by ghosts of the past? Drawing on archaeological, historical, and ethnographic data, Blurring Timescapes, Subverting Erasure demonstrates the value of conceiving of ghosts not just as metaphors, but as mechanisms for making the past more concrete and allowing the negative specters of enduring historical legacies, such as colonialism and capitalism, to be exorcised.